Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATXN17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | ATXN17 |
| Full Name | Ataxin-17 |
| Chromosome | 6p21.1 |
| Protein Type | Transcription Factor |
| Function | While ATXN17's specific biological functions are not well-characterized, it is understood to be part of the broader SCA17 genomic region: |
| Primary Expression | all tissues - High expression in: - Cerebellum (Purkinje cells) - Cerebral cortex (neurons) - Basal ganglia - [Hippoc |
| UniProt ID | Q9UH73 |
| NCBI Gene ID | 80022 |
| Ensembl ID | ENSG00000204237 |
| OMIM | 607786 |
| GeneCards | ATXN17 |
| Human Protein Atlas | ATXN17 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
A["ATXN17<br/>(Ataxin-17)"]
B["Protein Misfolding"]
C["Polyglutamine Expansion"]
D["Neuronal Dysfunction"]
E["Synaptic Transmission<br/>Defects"]
F["Mitochondrial<br/>Dysfunction"]
G["Oxidative Stress"]
H["Calcium Homeostasis<br/>Disruption"]
I["Neuroinflammation"]
J["Apoptosis"]
K["Neurodegeneration"]
L["Spinocerebellar<br/>Ataxia"]
M["HSP70<br/>(Heat Shock Proteins)"]
N["Autophagy<br/>Machinery"]
A -->|"causes"| C
C -->|"leads to"| B
B -->|"triggers"| D
D -->|"impairs"| E
D -->|"disrupts"| F
F -->|"increases"| G
G -->|"disturbs"| H
H -->|"activates"| I
I -->|"promotes"| J
J -->|"results in"| K
K -->|"manifests as"| L
M -->|"attempts to refold"| B
N -->|"clears"| B
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff
class A central
class M,N protective
class B,C,D,E,F,G,H,I,J,K pathological
class L disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity