Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Allosteric modulators: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| tau-HSP90 interaction destabilization | activates | mechanism | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Fractalkine Axis Amplification via CX3CR1 Positive Allosteri | 0.563 | neurodegeneration | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
drug discovery | 2026-04-09 | 7 hypotheses Top: 0.455
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Microglial TREM2 Agonist In Vivo Efficacy | validation | Alzheimer's Disease | 0.450 | 0.50 | mouse | proposed | $360,000 |
| TREM2 Agonist Therapy for Parkinson's Disease — Experimental Design | validation | Parkinson's Disease | 0.450 | 0.50 | mouse | proposed | $280,000 |
| TREM2 Function in Alzheimer's Disease — From Risk Variant to Therapeut | validation | Alzheimer's Disease | 0.450 | 0.50 | human | proposed | $2,960,000 |
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Synaptic pruning by microglia in ea | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $240,000 |
| DLB Treatment Response Biomarkers — Predicting Cholinesterase Inhibito | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| FTD Microglia Role: Protective vs Destructive Mechanism Study | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Microglial Aging and Immune Memory in Neurodegeneration — Training the | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Microglial Contributions to Huntington's Disease Pathogenesis | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via [PMID:37465997] | Chen X, He X, Xu F, Xu N, Sharifi NH, Zh | Stroke | 2023 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. [PMID:34492237] | Subbarayan MS, Joly-Amado A, Bickford PC | Pharmacol Ther | 2022 | 1 |
| Microglia in neurodegeneration. [PMID:30258234] | Hickman S, Izzy S, Sen P, Morsett L, El | Nat Neurosci | 2018 | 1 |
| How neuroinflammation contributes to neurodegeneration. [PMID:27540165] | Ransohoff RM | Science | 2016 | 1 |
| CX3CL1/CX3CR1 axis dysregulation contributes to epileptogenic mechanisms in foca [PMID:41863015] | Lei Lei; Shengyu Yang; Yinchao Li; Jiaha | Acta neuropathologica communic | 2026 | 0 |
| Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects [PMID:41924777] | Mroue-Ruiz FH, Desai B, Garvin MM, Shehu | Biochemical and biophysical re | 2026 | 0 |
| Systems-level molecular and immunological evidence identifies Th17/Treg modulati [PMID:41788408] | ["Li X", "Li X", "Chen S", "Wang L", "Xi | Frontiers in aging neuroscienc | 2026 | 0 |
| Multimodal tumor thermal therapy enhances antitumor immunity by expanding tumor- [PMID:41799205] | ["Wang S", "Wang Y", "Zhang Y", "Zhang Z | Theranostics | 2026 | 0 |
| [Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acu [PMID:41930567] | Zhang Z, Yang W, Ying R, Shi Y, Jiang H | Int J Mol Med | 2026 | 0 |
| CX3CR1-T280M polymorphism and end-stage renal disease development in chronic kid [PMID:41932952] | Matteo Gatti; Ivano Baragetti; Andrea Ba | Scientific reports | 2026 | 0 |
| SYK-dependent lipid handling in monocyte-derived macrophages governs functional [PMID:41831796] | ["Zhao Y", "Hu H", "Wang J", "Hu Y", "Ya | Brain research bulletin | 2026 | 0 |
| Microglial Lag3 Drives α-Synuclein-induced Neurotoxic Activated (A1) Astrocytes [PMID:41542562] | ["Yang X", "Kumbhar R", "Seo B", "Ha S", | bioRxiv : the preprint server | 2026 | 0 |
| Conserved ductular reaction mechanisms in biliary atresia and PSC derived from s [PMID:41903685] | Schofield A, Kamath BM, MacParland SA, T | Cellular and molecular gastroe | 2026 | 0 |
| Identification of suicide brain transcriptomic signatures using meta-analysis of [PMID:41916959] | Sokolov AV, Lafta MS, Jokinen J, Schiöth | Translational psychiatry | 2026 | 0 |
| Helper T cells and chemokines in elderly asthma - Mechanisms of airway inflammat [PMID:41805218] | ["Wu Y"] | Biomolecules & biomedicine | 2026 | 0 |
| Identification of metabolism and inflammation-related biomarkers and potential d [PMID:41781900] | ["Chen Y", "Zhang M", "Qiao L", "Lu F", | BMC psychiatry | 2026 | 0 |
| Chemokine Networks in Blood-Brain Barrier Regulation: Bidirectional Mechanisms, [PMID:41897331] | ["Wu Q", "Miao Z", "Lei W", "Wu X", "Zha | Biomolecules | 2026 | 0 |
| Two-Sample Bidirectional Mendelian Randomization Analysis of the Causal Relation [PMID:41878553] | ["Niu W", "Li J", "Jia H", "Wang L", "Xu | Clinical, cosmetic and investi | 2026 | 0 |
| Distinct NK Cell Signatures Define Prognosis in HPV-Positive Versus HPV-Negative [PMID:41827778] | ["Li R", "Tong F", "Liu H", "Liu Z", "Li | Cancers | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Allosteric modulators in their description or question text
No additional research found