ALPHA-KETOGLUTARATE DEHYDROGENASE

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALPHA-KETOGLUTARATE DEHYDROGENASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for Alpha-Ketoglutarate Dehydrogenase Protein

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flowchart TD
    Alpha_Ketoglutarate_Dehydrogen["Alpha-Ketoglutarate Dehydrogenase"] -->|"involved in"| Hepatic_Mitochondrial_Oxidatio["Hepatic Mitochondrial Oxidation"]
    MCU["MCU"] -->|"regulates"| Alpha_Ketoglutarate_Dehydrogen["Alpha-Ketoglutarate Dehydrogenase"]
    hepatic_mitochondrial_oxidatio["hepatic mitochondrial oxidation"] -->|"involved in"| palmitate_oxidation["palmitate oxidation"]
    Hepatic_Mitochondrial_Oxidatio["Hepatic Mitochondrial Oxidation"] -.->|"downregulates"| Hepatic_Triacylglycerol_Conten["Hepatic Triacylglycerol Content"]
    CAMKII["CAMKII"] -->|"activates"| HEPATIC_MITOCHONDRIAL_OXIDATIO["HEPATIC MITOCHONDRIAL OXIDATION"]
    CAMK2A["CAMK2A"] -->|"activates"| Hepatic_Mitochondrial_Oxidatio["Hepatic Mitochondrial Oxidation"]
    MCU["MCU"] -->|"regulates"| Mitochondrial_Calcium["Mitochondrial Calcium"]
    MCU["MCU"] -->|"mediates"| Mitochondrial_Calcium_Exchange["Mitochondrial Calcium Exchange"]
    MCU["MCU"] -->|"mediates"| MITOCHONDRIAL_CALCIUM_UPTAKE["MITOCHONDRIAL CALCIUM UPTAKE"]
    style Alpha_Ketoglutarate_Dehydrogen fill:#006494,stroke:#333,color:#e0e0e0
    style Hepatic_Mitochondrial_Oxidatio fill:#5d4400,stroke:#333,color:#e0e0e0
    style MCU fill:#006494,stroke:#333,color:#e0e0e0
    style hepatic_mitochondrial_oxidatio fill:#5d4400,stroke:#333,color:#e0e0e0
    style palmitate_oxidation fill:#5d4400,stroke:#333,color:#e0e0e0
    style Hepatic_Triacylglycerol_Conten fill:#5d2900,stroke:#333,color:#e0e0e0
    style CAMKII fill:#006494,stroke:#333,color:#e0e0e0
    style HEPATIC_MITOCHONDRIAL_OXIDATIO fill:#006494,stroke:#333,color:#e0e0e0
    style CAMK2A fill:#006494,stroke:#333,color:#e0e0e0
    style Mitochondrial_Calcium fill:#006494,stroke:#333,color:#e0e0e0
    style Mitochondrial_Calcium_Exchange fill:#5d4400,stroke:#333,color:#e0e0e0
    style MITOCHONDRIAL_CALCIUM_UPTAKE fill:#006494,stroke:#333,color:#e0e0e0