APOE4

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOE4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

APOE4 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 643 entities in the SciDEX knowledge graph.

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graph TD
    APOE4["APOE4"] -->|"contributes to"| amyloid_beta_deposits["amyloid beta deposits"]
    APOE4["APOE4"] -.->|"inhibits"| cognition["cognition"]
    APOE4["APOE4"] -->|"causes"| amyloid_pathology["amyloid pathology"]
    APOE4["APOE4"] -->|"associated"| AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"]
    APOE4["APOE4"] -->|"associated"| TAU_TANGLES["TAU TANGLES"]
    APOE4["APOE4"] -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    FN1["FN1"] -->|"protects against"| APOE4["APOE4"]
    TREM2["TREM2"] -->|"interacts"| APOE4["APOE4"]
    n_7C11["7C11"] -.->|"inhibits"| APOE4["APOE4"]
    APP["APP"] -.->|"inhibits"| APOE4["APOE4"]
    style APOE4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0