Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BICD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | BICD1 |
| Full Name | Bicaudal D1 |
| Protein Type | Gene |
| Function | is a cytoskeletal adaptor protein that plays essential roles in intracellular transport, neuronal development, and synaptic function. |
| GeneCards | BICD1 |
| Human Protein Atlas | BICD1 |
| Coiled-coil domains | Multiple coiled-coil regions throughout the protein mediate homodimerization and interactions with dynein-dynactin |
| Dynein binding domain (DBD) | C-terminal region that directly binds to dynein light chains (DYNLT1/2/3) |
| Dynactin binding site | N-terminal region that interacts with the p150^Glued subunit of dynactin |
| Cargo-binding domains | Central regions that recognize specific cargo adaptors and vesicles |
| Microtubule orientation | Neuronal microtubules are oriented with plus ends toward synapses and minus ends toward the cell body |
| Retrograde direction | Dynein-dynactin moves cargo toward the minus end (cell body direction) |
| Processive movement | Single dynein-dynactin complexes can traverse micrometer-scale distances along microtubules |
| Motor coordination | BICD1 helps coordinate multiple motors for efficient cargo transport |
| Synaptic vesicle precursors | Transport of newly synthesized synaptic proteins from the cell body to presynaptic terminals |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BICD1["BICD1"]
neurodegeneration["neurodegeneration"]
BICD1 -->|"implicated_in"| neurodegeneration
style BICD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BICD1 in their description or question text
No additional research found