BID

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolBID
NameBH3 interacting domain death agonist
Typeprotein-coding
Sourcemygene

Summary

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Au

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