Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BSCL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | BSCL2 |
| Chromosome | 11q13.1. |
| Function | Located in the ER membrane, seipin forms oligomeric complexes that facilitate the nucleation and growth of lipid droplets 1. |
| Primary Expression | cortical and cerebellar neurons, with particular enrichment in Purkinje cells and hippocampal pyramidal neurons [3](https://pubmed |
| Ensembl ID | ENSG00000128590 |
| GeneCards | BSCL2 |
| Human Protein Atlas | BSCL2 |
| gene = BSCL2 | name = BSCL2 Lipid Droplet Biogenesis Associated (Seipin) [@wang2015] |
| ncbi_gene_id = 27171 [@liu2021] | ensembl = ENSG00000128590 [@berardinelli1954] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BSCL2["BSCL2"]
neurodegeneration["neurodegeneration"]
BSCL2 -->|"implicated_in"| neurodegeneration
style BSCL2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity