protein

Bdnf

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Bdnf: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5378Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	SH
Full Name	SY5Y Cell Line
Chromosome	11p14.1
Protein Family	Neurotrophin family
Protein Type	Ligand
Target Class	Ligand
Function	Protein replacement therapy or small molecule mimetic
Mechanism of Action	Protein replacement therapy or small molecule mimetic
Primary Expression	Secreted, Synaptic vesicles
Druggability	Low (0.29)
Clinical Stage	Phase II
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Cholesterol
UniProt ID	P23560
NCBI Gene ID	627
Ensembl ID	ENSG00000176697
OMIM	113505
GeneCards	SH
Human Protein Atlas	SH
Associated Diseases	Addiction, Aging, Als, Alzheimer, Anxiety, Bipolar
Known Drugs/Compounds	Dihexa
Interactions	BDNF, AUTOPHAGY, NGF, CHR2, JUN, NEURON
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	Hippocampal CA3-CA1 synaptic rescue via DHHC2-medi Hippocampal CA3-CA1 circuit rescue via neurogenesi Neuroplasticity-Enhanced Learning Hypothesis
KG Connections	644 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: Bdnf — PDB 1B8M Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Bdnf["Bdnf"] -->|"encodes"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Bdnf["Bdnf"] -->|"encodes"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Bdnf["Bdnf"] -->|"encodes"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Bdnf["Bdnf"] -->|"activates"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Bdnf["Bdnf"] -.->|"inhibits"| Ptsd["Ptsd"]
    style Ptsd fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Bdnf["Bdnf"] -->|"activates"| Depression["Depression"]
    style Depression fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Bdnf["Bdnf"] -->|"activates"| Diabetes["Diabetes"]
    style Diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ELAVL2["ELAVL2"] -->|"encodes"| Bdnf["Bdnf"]
    style ELAVL2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SNAP29["SNAP29"] -->|"encodes"| Bdnf["Bdnf"]
    style SNAP29 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FUS["FUS"] -->|"encodes"| Bdnf["Bdnf"]
    style FUS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TDP_43["TDP-43"] -->|"encodes"| Bdnf["Bdnf"]
    style TDP_43 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    STX17["STX17"] -->|"encodes"| Bdnf["Bdnf"]
    style STX17 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Bdnf fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (3504)

Target	Relation	Type	Str
Aging	encodes	disease	0.60
Neurodegeneration	encodes	disease	0.60
Als	encodes	disease	0.60
Als	activates	disease	0.60
Aging	activates	disease	0.60
Stroke	activates	disease	0.60
Ptsd	inhibits	disease	0.60
Als	inhibits	disease	0.60
Depression	activates	disease	0.60
Als	contributes_to	disease	0.60
Aging	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Als	associated_with	disease	0.60
Diabetes	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Alzheimer	activates	disease	0.60
Bipolar	associated_with	disease	0.60
Schizophrenia	associated_with	disease	0.60
Depression	associated_with	disease	0.60
Opioid	associated_with	disease	0.60
Addiction	associated_with	disease	0.60
Aging	biomarker_for	disease	0.60
Fibrosis	biomarker_for	disease	0.60
Senescence	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Neurodegeneration	biomarker_for	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Depression	therapeutic_target	disease	0.60
Neurodegeneration	interacts_with	disease	0.60
Neurodegeneration	causes	disease	0.60
Alzheimer	causes	disease	0.60
Als	causes	disease	0.60
Diabetes	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Depression	inhibits	disease	0.60
Obesity	inhibits	disease	0.60
Depression	regulates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Autism	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Obesity	activates	disease	0.60
Parkinson	activates	disease	0.60
Depression	interacts_with	disease	0.60
Lymphoma	phosphorylates	disease	0.60
Als	regulates	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60

Incoming (1874)

Source	Relation	Type	Str
ELAVL2	encodes	gene	0.60
SNAP29	encodes	gene	0.60
FUS	encodes	gene	0.60
TDP-43	encodes	gene	0.60
STX17	encodes	gene	0.60
RAB5	encodes	gene	0.60
CLPP	encodes	gene	0.60
BDNF	activates	gene	0.60
ALS	encodes	gene	0.60
IGF2BP1	encodes	gene	0.60
MAPK	encodes	gene	0.60
RAB11	encodes	gene	0.60
YTHDF1	encodes	gene	0.60
AUTOPHAGY	activates	gene	0.60
METTL3	encodes	gene	0.60
NGF	activates	gene	0.60
CHR2	activates	gene	0.60
JUN	activates	gene	0.60
NEURON	activates	gene	0.60
STROKE	activates	gene	0.60
CALCA	inhibits	gene	0.60
CRH	encodes	gene	0.60
NR3C1	inhibits	gene	0.60
CRHR1	inhibits	gene	0.60
RAMP1	inhibits	gene	0.60
IL18BP	inhibits	gene	0.60
BDNF	encodes	gene	0.60
FKBP5	encodes	gene	0.60
IL18	encodes	gene	0.60
GLP1R	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
GFRAL	contributes_to	gene	0.60
SYN3	activates	gene	0.60
TRKB	activates	gene	0.60
DEPRESSION	activates	gene	0.60
EXERCISE	activates	gene	0.60
BDNF	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60
TRKB	causes	gene	0.60
AGING	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
CREB	expressed_in	gene	0.60
TRKB	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
IL-10	activates	gene	0.60
IGF1R	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific circulating factors in exercise-conditioned plasma that me

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Bdnf

Understanding Entity Pages

Wiki Pages (21)

SH-SY5Y Cell Line

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nimodipine-als

Neuroresilience Mechanisms and Evidence

Therapeutics

neuroinflammation

CBS/PSP Treatment Rankings

Multiple System Atrophy

Alzheimer's Disease

nct07165106

PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy