Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C1q binding: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| disease-altered glycans | causes | biomarker | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE isoform modifies the C1q binding landscape, biasing C1q | 0.590 | neurodegeneration | Does C1q function differ based on subcel |
| C1q Binding to Specific Synaptic Proteomes via Neurexin/Neur | 0.522 | synaptic-biology | What determines the selectivity of compl |
| Direct C1q Binding Enables FcγR-Independent Complement Activ | 0.148 | molecular-biology | Does Alectinib truly bind C1q directly w |
| Human Serum Albumin-Mediated Displacement Creates False-Posi | 0.132 | molecular-biology | Does Alectinib truly bind C1q directly w |
| C1q Binding Reflects Broader Kinase Inhibitor Promiscuity Ra | 0.124 | molecular-biology | Does Alectinib truly bind C1q directly w |
| C1q Binding Analysis Across ALK Inhibitor Chemical Series Wo | 0.115 | molecular-biology | Does Alectinib truly bind C1q directly w |
| Alectinib's Putative C1q Binding Derives from Hydrophobic Ag | 0.105 | molecular-biology | Does Alectinib truly bind C1q directly w |
Scientific analyses that reference this entity
molecular biology | 2026-04-21 | 1 hypotheses Top: 0.582
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274] | Xu F, Han L, Wang Y, Deng D, Ding Y, Zha | BMC Med | 2023 | 2 |
| Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in [PMID:37235660] | Chung HY, Wickel J, Hahn N, Mein N, Schw | Science advances | 2023 | 0 |
| Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and th [PMID:33628204] | Kovács, Vadászi, Bulyáki, | Frontiers in immunology | 2021 | 0 |
| Complement System in Neural Synapse Elimination in Development and Disease. [PMID:28826529] | ["Presumey J", "Bialas A", "Carroll M"] | Advances in immunology | 2017 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning C1q binding in their description or question text
Score: 0.115 · molecular-biology · 2026-04-18
## Mechanistic Overview C1q Binding Analysis Across ALK Inhibitor Chemical Series Would Resolve Specificity starts from
Score: 0.105 · molecular-biology · 2026-04-18
## Mechanistic Overview Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Than Direct Protein