Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CACNB2 |
| Chromosome | 10p12.31 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues including heart, brain, and endocrine cells, and is associated with multiple neurological and cardiovascular disorders[@j2019] |
| Subcellular Localization | and regulatory properties |
| Molecular Weight | 56.7 kDa |
| Exons | 13 |
| Ensembl ID | ENSG00000165995 |
| GeneCards | CACNB2 |
| Human Protein Atlas | CACNB2 |
| SH3 domain (SRC homology 3) | Located at the N-terminus, involved in protein-protein interactions |
| Kinase domain (PKA target) | Contains serine/threonine residues phosphorylated by protein kinase A |
| C-terminal tail | Contains additional regulatory sites for phosphorylation and protein interactions |
| Activation | β2 subunits typically accelerate activation |
| Inactivation | They modulate both voltage-dependent and calcium-dependent inactivation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CACNB2["CACNB2"]
neurodegeneration["neurodegeneration"]
CACNB2 -->|"implicated_in"| neurodegeneration
style CACNB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CACNB2 in their description or question text
No additional research found