Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNB4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CACNB4 |
| Chromosome | 2q22.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain, particularly in the cerebellum and hippocampus, where it plays critical roles in synaptic transmission, neuronal excitability, and motor co |
| Molecular Weight | 58.5 kDa |
| Amino Acids | 597 aa |
| Ensembl ID | ENSG00000163070 |
| GeneCards | CACNB4 |
| Human Protein Atlas | CACNB4 |
| β4a | Full-length isoform with complete domain structure |
| β4b | Truncated isoform lacking the C-terminal regulatory domain |
| β4c | Brain-specific isoform with unique N-terminal sequence |
| SH3 domain | N-terminal src homology 3 domain for protein-protein interactions |
| Kinase domain | Contains serine/threonine residues subject to phosphorylation |
| VDID domain | Von Willebrand factor type A domain for alpha-1 subunit binding |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CACNB4["CACNB4"]
neurodegeneration["neurodegeneration"]
CACNB4 -->|"implicated_in"| neurodegeneration
style CACNB4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CACNB4 in their description or question text
No additional research found