gene

CACNG4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CACNG4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CACNG4 encodes TARP gamma-4, an auxiliary subunit of voltage-gated calcium channels and AMPA receptors, implicated in epilepsy, autism, and Alzheimer's disease.

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🧬 Gene Info

Gene Symbol	CACNG4
Full Name	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4
Chromosome	17q24.2
Function	is a human gene whose product encodes the TARP γ4 protein, a member of the transmembrane AMPA receptor regulatory proteins (TARPs) family[@tarp2012].
Primary Expression	the brain and functions as an auxiliary subunit of both voltage-gated calcium channels and AMPA receptors[@tarps2010]
Amino Acids	329 aa
UniProt ID	Q9Y6A2
Ensembl ID	ENSG00000154042
GeneCards	CACNG4
Human Protein Atlas	CACNG4
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CACNG4 — AlphaFold Q9Y6A2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CACNG4 - TARP Gamma-4 Calcium Channel Subunit

gene · 783 words

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Pathway Diagram

flowchart TD
    A["Upstream Regulators"] --> B["CACNG4"]
    B --> C["Molecular Mechanism"]
    C --> D["Cellular Effects"]
    D --> E["Pathological Consequences"]

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CACNG4 in their description or question text

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