gene

CALCNA1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CALCNA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CACNA1A Gene

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🧬 Gene Info

Gene Symbol	CALCNA1
Full Name	Calcium Voltage-Gated Channel Subunit Alpha1 A
Chromosome	19p13.2
Function	Synaptic Transmission: P/Q-type channels are the primary voltage-gated calcium channels at presynaptic terminals, triggering neurotransmitter release through their high-affinity calcium binding [@mint
Primary Expression	a cell-type specific manner:
UniProt ID	[O00555](https://www.uniprot.org/uniprot/O00555)
Ensembl ID	ENSG00000141837
GeneCards	CALCNA1
Human Protein Atlas	CALCNA1
Alpha-1A subunit	The pore-forming subunit encoded by CACNA1A
Alpha-2/delta subunit	Auxiliary subunit that modulates channel trafficking and function
Beta subunit	Auxiliary subunit that regulates channel kinetics
Gamma subunit	Auxiliary subunit that influences channel properties
Activation	Voltage-dependent opening at membrane potentials around -40 mV
Inactivation	Both voltage-dependent and calcium-dependent inactivation
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CACNA1A Gene

gene · 1605 words

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Pathway Diagram

graph TD
    CALCNA1["CALCNA1"]
    neurodegeneration["neurodegeneration"]
    CALCNA1 -->|"implicated_in"| neurodegeneration
    style CALCNA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CALCNA1 in their description or question text

No additional research found