gene

CALM5

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CALM5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

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🧬 Gene Info

Gene Symbol	CALM5
Full Name	Calmodulin 5
Chromosome	19q13.32
Function	Calmodulin functions as a primary calcium sensor in eukaryotic cells, translating changes in intracellular calcium concentrations into downstream cellular responses:
Primary Expression	various tissues, with particular significance in: - Brain (cortex, hippocampus, cerebellum) - H
Amino Acids	149 aa
UniProt ID	[Q9NBU5](https://www.uniprot.org/uniprot/Q9NBU5)
Ensembl ID	ENSG00000169851
OMIM	614505
GeneCards	CALM5
Human Protein Atlas	CALM5
Phosphatases	Activates calcineurin (PP2B), linking calcium signals to dephosphorylation events
Ion Channels	Modulates voltage-gated calcium channels, NMDA receptors, and potassium channels
Transcription Factors	Activates CREB and other calcium-responsive transcription factors
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CALM5

gene · 934 words

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Pathway Diagram

graph TD
    CALM5["CALM5"]
    neurodegeneration["neurodegeneration"]
    CALM5 -->|"implicated_in"| neurodegeneration
    style CALM5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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