protein

CALMODULIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALMODULIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	CALMODULIN1
Protein Family	Calmodulin family, EF-hand calcium binding proteins
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	149 aa
UniProt ID	P0DP23
GeneCards	CALMODULIN1
Human Protein Atlas	CALMODULIN1
N-terminal domain	Two EF-hand calcium-binding motifs
C-terminal domain	Two EF-hand calcium-binding motifs
Flexible central linker	Allows domain movement upon calcium binding
Phosphatases	Calcineurin (PPP3CA)
Ion channels	Ca²⁺ channels, Na⁺ channels, K⁺ channels
Transcription factors	CREB, NFAT
Synaptic plasticity	CaMKII activation
Gene expression	CREB-mediated transcription
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CALMODULIN1 — AlphaFold P0DP23 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calmodulin-1 (CaM)

protein · 572 words

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Pathway Diagram

graph TD
    CALMODULIN1["CALMODULIN1"]
    neurodegeneration["neurodegeneration"]
    CALMODULIN1 -->|"implicated_in"| neurodegeneration
    style CALMODULIN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CALMODULIN1 in their description or question text

No additional research found