gene

CARS2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CARS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Mitochondrial Cysteinyl-tRNA Synthetase - mitochondrial translation in neurodegeneration

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🧬 Gene Info

Gene Symbol	CARS2
Aliases	Mitochondrial Cysteinyl-tRNA Synthetase
Protein Type	Synthetase
Function	tRNA Recognition: CARS2 specifically recognizes mitochondrial tRNA^Cys, which contains the characteristic anticodon sequence 5'-GCA-3' (read as cysteine codon).
Molecular Weight	80 kDa
Amino Acids	708 aa
Ensembl ID	ENSG00000156206
GeneCards	CARS2
Human Protein Atlas	CARS2
Activation	CARS2 first forms an aminoacyl-adenylate (aa-AMP) intermediate using ATP
Transfer	The activated amino acid is transferred to the 3'-terminal adenosine of tRNA^Cys, forming aminoacyl-tRNA
Catalytic domain	Core aminoacylation domain characteristic of class II synthetases
C-terminal domain	May contribute to tRNA binding and dimerization
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CARS2

gene · 1675 words

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Pathway Diagram

graph TD
    CARS2["CARS2"]
    neurodegeneration["neurodegeneration"]
    CARS2 -->|"implicated_in"| neurodegeneration
    style CARS2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CARS2 in their description or question text

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