Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CASP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Caspase-10 gene involved in apoptosis, necroptosis, and immune regulation with implications for Alzheimer's and Parkinson's disease
| Gene Symbol | CASP10 |
| Chromosome | 2q33.3 |
| Function | is an initiator caspase that transduces death signals from cell surface receptors to the intracellular cell death machinery[@caspase2020]. |
| Amino Acids | 521 aa |
| Ensembl ID | ENSG00000127334 |
| GeneCards | CASP10 |
| Human Protein Atlas | CASP10 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CASP10["CASP10"]
neurodegeneration["neurodegeneration"]
CASP10 -->|"implicated_in"| neurodegeneration
style CASP10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||