Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CAV32PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CAV32PROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | </strong></td><td>Dendrites, cell body, axon initial segment</td></tr> |
| Molecular Weight | 240 kDa |
| Amino Acids | 2353 aa |
| GeneCards | CAV32PROTEIN |
| Human Protein Atlas | CAV32PROTEIN |
| Four Homologous Domains (I-IV) | Each containing 6 transmembrane segments (S1-S6) |
| Voltage Sensor | S1-S4 segments detect membrane depolarization |
| Pore Region | S5-S6 segments form the ion conduction pathway |
| Selectivity Filter | Characteristic EEEE motif determining Ca²⁺ selectivity |
| Low Voltage Activation | Opens at voltages around -70 to -50 mV |
| Rapid Inactivation | Fast inactivation kinetics (tau ~20-50 ms) |
| Window Current | Sustained current at subthreshold voltages |
| Rebound Depolarization | Triggers low-threshold calcium spikes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CAV32PROTEIN["CAV32PROTEIN"]
neurodegeneration["neurodegeneration"]
CAV32PROTEIN -->|"implicated_in"| neurodegeneration
style CAV32PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CAV32PROTEIN in their description or question text
No additional research found