Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCNK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CCNK |
| Aliases | Cyclin K gene |
| Function | The CCNK gene encodes Cyclin K, a 580-amino acid protein |
| Primary Expression | human tissues with highest expression in testis, thymus, and bone marrow |
| Amino Acids | 580 aa |
| Ensembl ID | ENSG00000110075 |
| GeneCards | CCNK |
| Human Protein Atlas | CCNK |
| Transcriptional Elongation | Partners with CDK9 to form P-TEFb, which phosphorylates RNA polymerase II CTD and negative elongation factors to enable productive transcription<sup>[3]</sup>. |
| DNA Damage Response | CCNK-CDK9 complex is recruited to sites of DNA damage and regulates expression of DNA repair genes. |
| Cell Cycle Progression | Regulates G1/S and G2/M transitions through transcription of cell cycle genes. |
| Spliceosome Regulation | Involved in alternative splicing through interactions with the spliceosome. |
| Chromatin Remodeling | Associates with various chromatin remodeling complexes to regulate gene expression. |
| Cancer | Overexpression of CCNK observed in multiple cancers including breast, lung, and colorectal cancer. CCNK promotes tumor progression through sustained proliferation signals. |
| Neurodegeneration | Dysregulation of CCNK-CDK9 axis contributes to neuronal death in Alzheimer's disease through impaired transcription of neuroprotective genes. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CCNK["CCNK"]
neurodegeneration["neurodegeneration"]
CCNK -->|"implicated_in"| neurodegeneration
style CCNK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity