Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDK5R1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CDK5R1 |
| Aliases | Cyclin-Dependent Kinase 5 Regulatory Subunit 1, p35/p25, CDK5 Activator 1 |
| Protein Family | CDK5 activator family |
| Protein Type | Kinase |
| Function | Instead, p35 (and its paralogue p39) serves as the exclusive activator in neurons[@tsai1994]. |
| Primary Expression | Neuron-specific; high expression in cortex, hippocampus, cerebellum, basal ganglia |
| Molecular Weight | 35 kDa |
| Amino Acids | 350 aa |
| UniProt ID | Q15078 |
| NCBI Gene ID | 8851 |
| Ensembl ID | ENSG00000108395 |
| GeneCards | CDK5R1 |
| Human Protein Atlas | CDK5R1 |
| Full name | Cyclin-Dependent Kinase 5 Regulatory Subunit 1 |
| Chromosomal locus | 17q11.2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CDK5R1["CDK5R1"]
neurodegeneration["neurodegeneration"]
CDK5R1 -->|"implicated_in"| neurodegeneration
style CDK5R1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CDK5R1 in their description or question text
No additional research found