gene

CEP164

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CEP164: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CEP164 (Centrosomal Protein 164) is a key component of the centrosome and primary cilia, essential for ciliogenesis, cell cycle progression, and DNA damage response. Mutations cause nephronophthisis and related ciliopathies, with emerging links to neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	CEP164
Full Name	Centrosomal Protein 164
Chromosome	11q13.2
Function	is a critical component of the centrosome and primary cilia, serving as a master regulator of ciliogenesis and cell cycle progression [graber2007](https://pubmed.
Subcellular Localization	```mermaid
Molecular Weight	164 kDa
Amino Acids	1463 aa
Exons	37
Ensembl ID	ENSG00000110237
GeneCards	CEP164
Human Protein Atlas	CEP164
Centrosome maturation	Promotes centrosome separation and maturation
Spindle assembly	Ensures proper mitotic spindle formation
G1/S transition	Controls entry into S phase
G2/M checkpoint	Participates in DNA damage checkpoints
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CEP164 — Centrosomal Protein 164

gene · 1460 words

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Pathway Diagram

graph TD
    CEP164["CEP164"]
    neurodegeneration["neurodegeneration"]
    CEP164 -->|"implicated in"| neurodegeneration
    Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
    CEP164 -->|"implicated in"| Neurodegenerative_Diseases
    Dna_Damage(["Dna Damage"])
    CEP164 -->|"involved in"| Dna_Damage
    ROS["ROS"]
    CEP164 ---|"interacts"| ROS
    style CEP164 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Neurodegenerative_Diseases fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Dna_Damage fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CEP164 in their description or question text

No additional research found