gene

CERK

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CERK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for CERK Gene

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🧬 Gene Info

Gene Symbol	CERK
Chromosome	22q13.31
Function	Substrate specificity: Prefers ceramide with C16:0, C18:0, C24:0, C24:1 acyl chains
Primary Expression	neurons and glia throughout the brain, with highest expression in hippocampus, [cortex](/brain-regi
Amino Acids	538 aa
Exons	11
Pathways	PI3K
Ensembl ID	ENSG00000100324
GeneCards	CERK
Human Protein Atlas	CERK
PH domain	Pleckstrin homology domain for membrane localization
Diacylglycerol kinase domain	Catalytic domain with ATP-binding site
C1 domain	Lipid-binding cysteine-rich region
Calcium/calmodulin regulation	Calcium-dependent activation
Microglial activation	C1P promotes pro-inflammatory phenotype
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CERK Gene

gene · 883 words

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Pathway Diagram

flowchart TD
    A["Upstream Regulators"] --> B["CERK"]
    B --> C["Molecular Mechanism"]
    C --> D["Cellular Effects"]
    D --> E["Pathological Consequences"]

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CERK in their description or question text

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