protein

CHD7PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CHD7PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CHD7 is a large chromatin remodeler protein comprising multiple functional domains that work in concert to regulate gene expression through ATP-dependent histone modification and chromatin restructuring 1.

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🔬 Protein Info

Gene Symbol	CHD7PROTEIN
Function	is a member of the CHD family of ATP-dependent chromatin remodelers that play critical roles in epigenetic regulation of gene expression during neural development, adult neurogenesis, and synaptic ...
Subcellular Localization	</th><td>Nucleus</td></tr>
Molecular Weight	336 kDa
GeneCards	CHD7PROTEIN
Human Protein Atlas	CHD7PROTEIN
Neural Plate Border Specification	CHD7 regulates expression of neural crest specification genes including FOXD3, SOX10, and SNAIL
Migration and Differentiation	Controls genes required for neural crest cell migration and lineage specification
Epithelial-Mesenchymal Transition (EMT)	Modulates EMT programs necessary for neural crest delamination
Forebrain Development	Regulates patterning of the forebrain and调节 neural progenitor cell specification
Hypothalamic Function	Critical for hypothalamic development, which controls endocrine functions and homeostasis
Cerebellar Development	Involved in cerebellar granule neuron precursor proliferation
Cortical Neurogenesis	Regulates cortical progenitor cell proliferation and differentiation
Hippocampal Neurogenesis	Regulates neural progenitor cell proliferation in the dentate gyrus
Olfactory Bulb Neurogenesis	Controls generation of new neurons in the subventricular zone-olfactory bulb pathway
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

chd7-protein

protein · 1840 words

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Pathway Diagram

graph TD
    CHD7PROTEIN["CHD7PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CHD7PROTEIN -->|"implicated_in"| neurodegeneration
    style CHD7PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning CHD7PROTEIN in their description or question text

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