gene

CHRNA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHRNA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for CHRNA3 — Cholinergic Receptor Nicotinic Alpha 3

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🧬 Gene Info

Gene Symbol	CHRNA3
Full Name	Cholinergic Receptor Nicotinic Alpha 3
Chromosome	15q25.1
Protein Type	Receptor
Function	is a member of the Cys-loop receptor superfamily, similar to CHRNA2, but with distinct expression patterns and physiological roles.
Primary Expression	autonomic ganglia and plays a crucial role in peripheral cholinergic transmission, autonomic function, and cognitive processes
Molecular Weight	57 kDa
Amino Acids	25 aa
UniProt ID	[P30531](https://www.uniprot.org/uniprotkb/P30531)
Ensembl ID	ENSG00000138028
GeneCards	CHRNA3
Human Protein Atlas	CHRNA3
Extracellular N-terminal domain	ACh binding site
Transmembrane domain	Four α-helices (M1-M4)
Intracellular loop	Between M3 and M4
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CHRNA3 — Cholinergic Receptor Nicotinic Alpha 3

gene · 1020 words

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CHRNA3 Protein

protein · 521 words

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Pathway Diagram

graph TD
    CHRNA3["CHRNA3"]
    neurodegeneration["neurodegeneration"]
    CHRNA3 -->|"implicated_in"| neurodegeneration
    style CHRNA3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CHRNA3 in their description or question text

No additional research found