gene

CHRNA4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CHRNA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Cholinergic Receptor Nicotinic Alpha Subunit 4

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🧬 Gene Info

Gene Symbol	CHRNA4
Full Name	Cholinergic Receptor Nicotinic Alpha Subunit 4
Chromosome	20q13.31
Protein Type	Channel
Function	Nicotinic α4β2 receptor function
UniProt ID	P43681
NCBI Gene ID	1137
Ensembl ID	ENSG00001202073
OMIM	118504
GeneCards	CHRNA4
Human Protein Atlas	CHRNA4
Ion channel	Permits Na+ and Ca2+ influx
Cognitive enhancement	Nicotinic agonists
Reward processing	Mesolimbic dopamine modulation
Wide distribution	Cortex, hippocampus, thalamus
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHRNA4 — AlphaFold P43681 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cholinergic Receptor Nicotinic Alpha Subunit 4

gene · 639 words

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Pathway Diagram

graph TD
    CHRNA4["CHRNA4"]
    neurodegeneration["neurodegeneration"]
    CHRNA4 -->|"implicated_in"| neurodegeneration
    style CHRNA4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHRNA4 in their description or question text

No additional research found