Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNB4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | Cholinergic Receptor Nicotinic Beta Subunit 4 |
| Aliases | CHRNB4 |
| Chromosome | 15q25.1 |
| Protein Family | Cys-loop receptor family |
| Function | is a 498-amino acid transmembrane subunit that assembles with other α and β subunits to form functional nAChR channels. |
| Amino Acids | 498 aa |
| NCBI Gene ID | 1143 |
| Peripheral nervous system | Autonomic ganglia, adrenal medulla |
| Brain regions | Hippocampus, cortex, thalamus, basal ganglia |
| Neuroendocrine cells | Chromaffin cells, pineal gland |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNB4["CHRNB4"]
neurodegeneration["neurodegeneration"]
CHRNB4 -->|"implicated_in"| neurodegeneration
style CHRNB4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CHRNB4 in their description or question text
No additional research found