gene

CHST14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHST14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CHST14 (D4ST1) is a dermatan sulfate sulfotransferase involved in extracellular matrix assembly, glycosaminoglycan biosynthesis, and implicated in Ehlers-Danlos syndrome and wound healing.

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🧬 Gene Info

Gene Symbol	CHST14
Full Name	Carbohydrate Sulfotransferase 14
Aliases	D4ST1, Page for CHST14 Protein
Chromosome	19p13.12
Protein Type	Enzyme
Function	is a crucial enzyme in the biosynthesis of dermatan sulfate proteoglycans.
Molecular Weight	48 kDa
Amino Acids	424 aa
Exons	3
UniProt ID	[Q8IWW4](https://www.uniprot.org/uniprot/Q8IWW4)
Ensembl ID	ENSG00000110876
GeneCards	CHST14
Human Protein Atlas	CHST14
N-terminal transmembrane domain	Type II membrane protein orientation
Stem region	Projects into the Golgi lumen
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CHST14 - Carbohydrate Sulfotransferase 14

gene · 998 words

→

CHST14 Protein - Dermatan 4-O-Sulfotransferase 1

protein · 590 words

→

Pathway Diagram

graph TD
    CHST14["CHST14"]
    neurodegeneration["neurodegeneration"]
    CHST14 -->|"implicated_in"| neurodegeneration
    style CHST14 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHST14 in their description or question text

No additional research found