gene

CLCN2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CLCN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CLCN2 Gene

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🧬 Gene Info

Gene Symbol	CLCN2
Full Name	Chloride Voltage-Gated Channel 2
Chromosome	3q27.1
Function	The CLCN2 gene encodes the chloride voltage-gated channel 2 (ClC-2), a voltage-gated chloride channel belonging to the CLC channel/transporter family.
Primary Expression	neurons and glia, involved in neuronal excitability, cell volume regulation, and GABAergic inhibition
Subcellular Localization	presynaptic terminals and postsynaptic densities, where it modulates synaptic transmission. It influences GABAergic inhi
UniProt ID	[P51788](https://www.uniprot.org/uniprot/P51788)
Ensembl ID	ENSG00000110958
GeneCards	CLCN2
Human Protein Atlas	CLCN2
Cerebellum	Purkinje cells and granule cells
Thalamus	Relay neurons
Substantia nigra	Dopaminergic neurons
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CLCN2 Gene

gene · 985 words

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Pathway Diagram

graph TD
    CLCN2["CLCN2"]
    neurodegeneration["neurodegeneration"]
    CLCN2 -->|"implicated_in"| neurodegeneration
    style CLCN2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning CLCN2 in their description or question text

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