gene

CLCN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLCN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for CLCN3 Gene

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🧬 Gene Info

Gene Symbol	Chloride Voltage-Gated Channel 3
Chromosome	4q22.1.
Protein Type	Channel
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the brain, particularly in the hippocampus, cortex, and cerebellum Citation needed
Exons	12
UniProt ID	P51790
NCBI Gene ID	1184
Ensembl ID	ENSG00000109572
OMIM	600570
Exon 1	5' UTR and N-terminal coding region
Exons 2-11	Transmembrane domain coding
Exon 12	C-terminal domain and 3' UTR
Brain	Highest expression in hippocampus, cerebral cortex, cerebellum
Synaptic vesicles	Major enrichment in presynaptic nerve terminals
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLCN3 — AlphaFold P51790 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CLCN3 Gene

gene · 666 words

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Pathway Diagram

graph TD
    CLCN3["CLCN3"]
    neurodegeneration["neurodegeneration"]
    CLCN3 -->|"implicated_in"| neurodegeneration
    style CLCN3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CLCN3 in their description or question text

No additional research found