gene

CLCN4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CLCN4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for CLCN4 Gene

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🧬 Gene Info

Gene Symbol	Chloride Voltage-Gated Channel 4
Chromosome	Xp22.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various tissues, with high expression in brain, heart, and skeletal muscle Citation needed
Subcellular Localization	intracellular compartments, particularly endosomes and lysosomes Citation needed. The gene is located on chromosome X (X
Exons	12
UniProt ID	P51863
NCBI Gene ID	1185
Ensembl ID	ENSG00000147316
OMIM	302950
Exons 1-2	5' UTR and N-terminal coding region
Exons 3-11	Transmembrane domain coding
Exon 12	C-terminal domain and 3' UTR
Brain	Neurons in cortex, hippocampus, cerebellum
Heart	Cardiac myocytes
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLCN4 — AlphaFold P51863 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CLCN4 Gene

gene · 700 words

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Pathway Diagram

graph TD
    CLCN4["CLCN4"]
    neurodegeneration["neurodegeneration"]
    CLCN4 -->|"implicated_in"| neurodegeneration
    style CLCN4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CLCN4 in their description or question text

No additional research found