Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CLCN5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CLCN5 |
| Full Name | Chloride Voltage-Gated Channel 5 |
| Chromosome | Xq11.23 |
| Protein Type | Channel |
| Function | The CLCN5 gene encodes ClC-5, a chloride channel essential for renal proximal tubule function. |
| Primary Expression | kidney proximal tubules and intestinal epithelium |
| Subcellular Localization | endosomes of the proximal tubule." *Pflügers Archiv*. PMID:9670513 |
| UniProt ID | P51795 |
| NCBI Gene ID | 1189 |
| Ensembl ID | ENSG00000071327 |
| OMIM | 300008 |
| GeneCards | CLCN5 |
| Human Protein Atlas | CLCN5 |
| Associated Diseases | Dent's Disease, Hypercalciuria, Proximal Tubule Dysfunction |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
CLCN5(["CLCN5"])
Dent_s_Disease["Dent's Disease"]
Proximal_Tubule_Dysfunction("Proximal Tubule Dysfunction")
Endocytosis("Endocytosis")
Hypercalciuria("Hypercalciuria")
Endosomal_Acidification("Endosomal Acidification")
neurodegeneration["neurodegeneration"]
CLCN5 -->|"causes"| Dent_s_Disease
CLCN5 -->|"causes"| Proximal_Tubule_Dysfunction
CLCN5 -->|"participates in"| Endocytosis
CLCN5 -->|"causes"| Hypercalciuria
CLCN5 -->|"participates in"| Endosomal_Acidification
CLCN5 -->|"implicated in"| neurodegeneration
style CLCN5 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Dent's Disease | causes | disease | 0.90 |
| Proximal Tubule Dysfunction | causes | phenotype | 0.90 |
| Hypercalciuria | causes | phenotype | 0.80 |
| Endosomal Acidification | participates_in | biological_process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||