gene

CLCN9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLCN9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

Summary

Voltage-gated chloride channel involved in lysosomal function and mineral metabolism

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🧬 Gene Info

Gene Symbol	CLCN9
Full Name	Chloride Voltage-Gated Channel 9
Chromosome	12q24.31.
Protein Type	Channel
Function	encodes a voltage-gated chloride channel of the CLCN family, located on chromosome 12q24.
Primary Expression	the proximal tubule and intercalated cells of the collecting duct
Subcellular Localization	intracellular organelles, particularly lysosomes and endosomes. In these compartments, chloride channels like CLC-9 play
Amino Acids	800 aa
GeneCards	CLCN9
Human Protein Atlas	CLCN9
Tissue	Expression Level
Bone (osteoclasts)	High
Kidney	Moderate
Brain	Low-Moderate
Liver	Low
Associated Diseases	Complex Human Diseases
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    CLCN9(["CLCN9"])
    Cell_Types["/"Cell Types"/"]
    Muscle_Fibers["/"Muscle Fibers"/"]
    Plasma_Proteome("Plasma Proteome")
    Complex_Human_Diseases["Complex Human Diseases"]
    Cardiac_Repolarization("Cardiac Repolarization")
    neurodegeneration["neurodegeneration"]

    CLCN9 -->|"expressed in"| Cell_Types
    CLCN9 -->|"expressed in"| Muscle_Fibers
    CLCN9 -->|"associated with"| Plasma_Proteome
    CLCN9 -->|"associated with"| Complex_Human_Diseases
    CLCN9 -->|"participates in"| Cardiac_Repolarization
    CLCN9 -->|"implicated in"| neurodegeneration

    style CLCN9 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
Cell Types	expressed_in	cell_type	0.80
Muscle Fibers	expressed_in	cell_type	0.70
Plasma Proteome	associated_with	biological_process	0.70
Complex Human Diseases	associated_with	disease	0.70
Cardiac Repolarization	participates_in	biological_process	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found