Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CNTFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CNTFR encodes the alpha subunit of the CNTF receptor, essential for neuronal survival and implicated in Alzheimer's, Parkinson's, and motor neuron diseases
| Gene Symbol | CNTFR |
| Full Name | Ciliary Neurotrophic Factor Receptor Alpha |
| Chromosome | 9p13.2 |
| Protein Type | Receptor |
| Function | CNTFRα mediates essential biological functions |
| Primary Expression | the nervous system[@benhamou2023]: |
| Molecular Weight | 45 kDa |
| Amino Acids | 400 aa |
| Exons | 8 |
| Gene Type | Protein coding |
| Pathways | JAK-STAT pathway, MAPK, PI3K |
| UniProt ID | P26992 |
| NCBI Gene ID | 1271 |
| Ensembl ID | ENSG00000122756 |
| OMIM | 118400 |
| GeneCards | CNTFR |
| Human Protein Atlas | CNTFR |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CNTFR["CNTFR"]
neurodegeneration["neurodegeneration"]
CNTFR -->|"implicated_in"| neurodegeneration
style CNTFR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||