gene

CNTNAP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNTNAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	CNTNAP1
Chromosome	17q21.2
Function	encodes a critical transmembrane cell adhesion molecule that plays essential roles in the organization and maintenance of myelinated axons in the nervous system.
Subcellular Localization	the paranodal regions of myelinated axons, where it forms specialized junctions with oligodendrocytes (in the central ne
Molecular Weight	160 kDa
Amino Acids	401 aa
Exons	24
Ensembl ID	ENSG00000170049
GeneCards	CNTNAP1
Human Protein Atlas	CNTNAP1
Human-Mouse	93% identical at the amino acid level
Human-Zebrafish	78% identical
Drosophila	Homolog (Nrg-180) with 45% identity
C. elegans	Homolog (NRC-1) with 35% identity
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CNTNAP1["CNTNAP1"]
    neurodegeneration["neurodegeneration"]
    CNTNAP1 -->|"implicated_in"| neurodegeneration
    style CNTNAP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CNTNAP1

Understanding Entity Pages

Wiki Pages (6)

cntnap1

CNTNAP3 Gene - Contactin Associated Protein 3

Paranodal Dysfunction in Neurodegeneration

Nodes of Ranvier

Contactin-1 - Biomarker for Peripheral Neuropathy