Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | COA7 |
| Full Name | Cytochrome C Oxidase Assembly Factor 7 |
| Chromosome | 1p32.3 |
| Function | is a mitochondrial protein essential for the assembly and maintenance of cytochrome c oxidase (Complex IV), the fourth complex of the electron transport chain. |
| Primary Expression | tissues with high oxidative phosphorylation requirements |
| Molecular Weight | 29 kDa |
| Amino Acids | 269 aa |
| UniProt ID | Q9BUK6 |
| NCBI Gene ID | 56504 |
| Ensembl ID | ENSG00000147403 |
| OMIM | 615623 |
| GeneCards | COA7 |
| Human Protein Atlas | COA7 |
| Mitochondrial Targeting Sequence | N-terminal targeting sequence directs the protein to mitochondria |
| Repeat Domains | Contains tetratricopeptide repeat (TPR)-like domains that mediate protein-protein interactions |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
COA7["COA7"]
mitochondrial_function["mitochondrial function"]
COA7 -->|"participates_in"| mitochondrial_function
neurodegeneration["neurodegeneration"]
COA7 -->|"implicated in"| neurodegeneration
style COA7 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning COA7 in their description or question text
No additional research found