gene

COG1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about COG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

COG1 — Conserved Oligomeric Golgi Complex 1

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🧬 Gene Info

Gene Symbol	COG1
Full Name	Conserved Oligomeric Golgi Complex 1
Chromosome	17q21.2
Function	encodes a core component of the COG complex, a heterotrimeric vesicle tethering complex essential for Golgi apparatus structure and function[@wu2004].
UniProt ID	Q8NHW3
NCBI Gene ID	2274
Ensembl ID	ENSG00000109805
OMIM	606978
GeneCards	COG1
Human Protein Atlas	COG1
Lobe A	COG1, COG2, COG3, COG4
Lobe B	COG5, COG6, COG7, COG8
Glycosyltransferases	COG maintains the proper localization and activity of glycosyltransferases in the Golgi cisternae[@ungar2005].
Glycan Processing	The complex ensures sequential processing of N-linked and O-linked glycans on proteins.
Quality Control	COG-mediated trafficking ensures only properly glycosylated proteins proceed through the secretory pathway[@foulquier2006].
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: COG1 — AlphaFold Q8NHW3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

COG1 — Conserved Oligomeric Golgi Complex 1

gene · 992 words

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Pathway Diagram

graph TD
    COG1["COG1"]
    neurodegeneration["neurodegeneration"]
    COG1 -->|"implicated_in"| neurodegeneration
    style COG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning COG1 in their description or question text

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