Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | COG3 |
| Full Name | Conserved Oligomeric Golgi Complex 3 |
| Chromosome | 13q14.11 |
| Function | COG3 is one of the core subunits essential for the structural integrity and function of lobe B of the complex[@miller2019]. |
| Amino Acids | 122 aa |
| GeneCards | COG3 |
| Human Protein Atlas | COG3 |
| Synaptic protein trafficking | Many synaptic proteins require proper Golgi-to-plasma membrane trafficking. COG3 mutations can impair synaptic protein delivery and function[@liu2019]. |
| Lysosomal trafficking | Proper function of the COG complex is essential for autophagy and lysosomal degradation pathways that clear misfolded proteins. |
| Mitochondrial protein trafficking | COG-mediated trafficking affects mitochondrial quality control mechanisms. |
| Protein homeostasis | Impaired Golgi trafficking disrupts protein quality control mechanisms essential for motor neuron survival. |
| Axonal transport | COG3 deficiency can impair axonal vesicle trafficking critical for neuromuscular junction function. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
COG3["COG3"]
neurodegeneration["neurodegeneration"]
COG3 -->|"implicated_in"| neurodegeneration
style COG3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity