Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COPB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | COPB2 |
| Full Name | Coatomer Protein Complex Subunit Beta 2 |
| Chromosome | 3q29 |
| Protein Family | Coatomer complex (COPI) |
| Function | encodes the beta prime subunit of the COPI (Coat Protein Complex I) coatomer complex |
| UniProt ID | P49407 |
| NCBI Gene ID | 9276 |
| Ensembl ID | ENSG00000185103 |
| OMIM | 607488 |
| GeneCards | COPB2 |
| Human Protein Atlas | COPB2 |
| Cargo recognition | COPB2 recognizes dilysine (KKXX) motifs in the cytoplasmic tails of transmembrane proteins |
| Vesicle formation | The coat polymerizes around the Golgi membrane to drive vesicle budding |
| Cargo sorting | Selectively incorporates cargo molecules into forming vesicles |
| Membrane deformation | Coordinates membrane curvature for vesicle formation |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Hereditary Spastic Paraplegia, Lysosomal Storage Disorders |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
COPB2["COPB2"]
neurodegeneration["neurodegeneration"]
COPB2 -->|"implicated_in"| neurodegeneration
style COPB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning COPB2 in their description or question text
No additional research found