Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COQ8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
COQ8A (ADCK3) encodes a mitochondrial protein kinase essential for coenzyme Q biosynthesis, with variants causing cerebellar ataxia and CoQ10 deficiency syndromes.
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| Gene Symbol | COQ8A |
| Full Name | Coenzyme Q Kinase ADCK3 |
| Aliases | ADCK3 |
| Chromosome | 14q24.3 |
| Protein Type | Kinase |
| Function | is a mitochondrial protein kinase belonging to the alpha-kinase family. |
| Molecular Weight | 75 kDa |
| Amino Acids | 645 aa |
| GeneCards | COQ8A |
| Human Protein Atlas | COQ8A |
| Alpha-kinase family | Uses an alternative catalytic mechanism compared to conventional protein kinases |
| Substrate | Phosphorylates coenzyme Q biosynthesis intermediates, specifically COQ7 (also known as COQ8B in yeast) |
| Activity regulation | Requires mitochondrial membrane potential and intact CoQ biosynthesis machinery |
| CoQ10 deficiency | Reduced CoQ10 levels impair Complex I function, increasing dopaminergic neuron vulnerability |
| LRRK2 interaction | COQ8A interacts with LRRK2, the most common genetic cause of familial PD |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
COQ8A["COQ8A"]
neurodegeneration["neurodegeneration"]
COQ8A -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning COQ8A in their description or question text
No additional research found