protein

CTNSPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTNSPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Cystinosin is a 367-amino acid polytopic membrane protein localized to the lysosomal membrane, where it functions as an H⁺-driven cystine transporter<sup>[1]</sup>.

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🔬 Protein Info

Gene Symbol	CTNSPROTEIN
Protein Type	Transporter
Function	is a lysosomal membrane transporter protein critical for cystine efflux from lysosomes.
Subcellular Localization	to the lysosomal membrane, where it functions as an H⁺-driven cystine transporte
Molecular Weight	42 kDa
GeneCards	CTNSPROTEIN
Human Protein Atlas	CTNSPROTEIN
N-terminal domain	Located in the lysosomal lumen, contains 7 N-glycosylation sites
Seven transmembrane helices (TM1-TM7)	Span the lysosomal membrane to form the cystine translocation pathway
Two PQ-loop motifs	Conserved Pro-Gln sequences in TM2 and TM5 essential for transport
C-terminal tail	Cytoplasmic, contains the GYDQL lysosomal sorting motif
Intralysosomal loops	Large glycosylated loops between TMs protect against lysosomal proteases
Autophagic flux	Reduced autophagosome-lysosome fusion
Chaperone-mediated autophagy	Impaired LAMP2A-dependent CMA
Endosomal trafficking	Delayed endosomal maturation and cargo sorting
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cystinosin (CTNS Protein)

protein · 888 words

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Pathway Diagram

graph TD
    CTNSPROTEIN["CTNSPROTEIN"]
    neurodegeneration["neurodegeneration"]
    CTNSPROTEIN -->|"implicated_in"| neurodegeneration
    style CTNSPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found