Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CUL4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CUL4A |
| Full Name | Cullin 4A |
| Chromosome | 13q34 |
| Protein Family | Cullin family |
| Function | encodes a member of the cullin family of proteins that serve as molecular scaffolds for multi-subunit ubiquitin ligase complexes. |
| Molecular Weight | 190 kDa |
| UniProt ID | Q13617 |
| NCBI Gene ID | 8451 |
| Ensembl ID | ENSG00000198242 |
| OMIM | 603137 |
| GeneCards | CUL4A |
| Human Protein Atlas | CUL4A |
| CUL4A core | Provides structural framework for complex assembly |
| RING finger protein ROC1/Rbx1 | Catalyzes ubiquitin transfer |
| DDB1 (DNA Damage Binding Protein 1) | Adaptor protein that connects CUL4A to substrate receptors |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, X-linked Mental Retardation, Cockayne Syndrome |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CUL4A["CUL4A"]
neurodegeneration["neurodegeneration"]
CUL4A -->|"implicated_in"| neurodegeneration
style CUL4A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CUL4A in their description or question text
No additional research found