protein

DAT1PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DAT1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	DAT1PROTEIN
Function	is a protein that dat plays essential roles in:.
Primary Expression	Substantia nigra pars compacta, ventral tegmental area, striatum
Molecular Weight	~79 kDa (705 amino acids)
Amino Acids	705 aa
UniProt ID	Q01953
GeneCards	DAT1PROTEIN
Human Protein Atlas	DAT1PROTEIN
DAT Downregulation	Progressive loss of DAT binding in PD patients observed via SPECT imaging (DaTscan)
Toxin-Induced PD	MPTP and 6-OHDA specifically target DAT to enter dopaminergic neurons
DAT Dysfunction	Reduced DAT activity may contribute to extracellular dopamine accumulation followed by progressive loss
Diagnostic Marker	DAT imaging is used to distinguish PD from non-degenerative parkinsonism
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DAT1PROTEIN — AlphaFold Q01953 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DAT1 (Dopamine Transporter) Protein

protein · 587 words

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Pathway Diagram

graph TD
    DAT1PROTEIN["DAT1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    DAT1PROTEIN -->|"implicated_in"| neurodegeneration
    style DAT1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning DAT1PROTEIN in their description or question text

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