Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLGAP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DLGAP3 (SAPAP3) is a postsynaptic density protein critical for synaptic scaffolding, receptor anchoring, and plasticity. This comprehensive page covers its structure, normal neuronal function, role in neurodegenerative diseases, and therapeutic potential.
| Gene Symbol | DLGAP3 |
| Aliases | SAPAP3 |
| Chromosome | 19p13.3 |
| Function | DLGAP3 (SAPAP3) is a postsynaptic density protein that plays a crucial role in excitatory synaptic transmission and plasticity. |
| Primary Expression | the brain, particularly in: - Cerebral cortex - Hippocampus - Striatum - [Cerebellum](/brain- |
| Molecular Weight | 109 kDa |
| Amino Acids | 854 aa |
| UniProt ID | O75180 |
| NCBI Gene ID | 58524 |
| Ensembl ID | ENSG00000153779 |
| GeneCards | DLGAP3 |
| Human Protein Atlas | DLGAP3 |
| Autism Spectrum Disorder | Rare variants in DLGAP3 have been identified in patients with ASD. |
| Intellectual Disability | Loss-of-function mutations contribute to intellectual disability phenotypes. |
| Obsessive-Compulsive Disorder | DLGAP3 (particularly SAPAP3/DLGAP3) has been linked to OCD-like behaviors in mouse models. |
| Associated Diseases | Autism Spectrum Disorder |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DLGAP3["<b>DLGAP3</b>"]
neurodegeneration["neurodegeneration"]
DLGAP3 -->|"implicated in"| neurodegeneration
Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
DLGAP3 -->|"implicated in"| Neurodegenerative_Diseases
style DLGAP3 fill:#1a4a3a,stroke:#81c784,stroke-width:3px,color:#fff
style Neurodegenerative_Diseases fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||