Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLGH2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DLGH2PROTEIN |
| Chromosome | 8p23.3 |
| Protein Type | Scaffold Protein |
| Function | is a fundamental component of the postsynaptic density, a specialized structure beneath the postsynaptic membrane that contains the machinery for synaptic signaling and plasticity. |
| Primary Expression | the brain, with particularly high levels in the hippocampus, olfactory bulb, cerebral cortex, and cerebellum |
| Amino Acids | 220 aa |
| Exons | 24 |
| GeneCards | DLGH2PROTEIN |
| Human Protein Atlas | DLGH2PROTEIN |
| TATA box | Located at position -30 relative to the transcription start site |
| GC-rich regions | Multiple Sp1 binding sites for basal transcription |
| Neural-specific enhancers | Binding sites for neuron-specific transcription factors including Ngn2 and NeuroD1 |
| Activity-dependent elements | CREB response elements enabling regulation by neuronal activity |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DLGH2PROTEIN["DLGH2PROTEIN"]
neurodegeneration["neurodegeneration"]
DLGH2PROTEIN -->|"implicated_in"| neurodegeneration
style DLGH2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DLGH2PROTEIN in their description or question text
No additional research found