Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DMC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DMC1 |
| Full Name | DNA Meiotic Recombinase 1 |
| Chromosome | 22q13.1 |
| Protein Type | Enzyme |
| Function | encodes a key recombinase enzyme essential for homologous recombination during meiosis and the repair of DNA double-strand breaks (DSBs). |
| Molecular Weight | 37 kDa |
| Amino Acids | 340 aa |
| Exons | 13 |
| NCBI Gene ID | 11144 |
| Ensembl ID | ENSG00000101339 |
| GeneCards | DMC1 |
| Human Protein Atlas | DMC1 |
| Nucleation | DMC1 initially binds to ssDNA at specific sites |
| Filament extension | Additional DMC1 monomers add to the filament |
| ATP-dependent stabilization | ATP binding stabilizes the filament |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
DMC1["DMC1"]
neurodegeneration["neurodegeneration"]
DMC1 -->|"implicated_in"| neurodegeneration
style DMC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DMC1 in their description or question text
No additional research found