gene

DNAJC22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DNAJC22 (DnaJ Heat Shock Protein Family Member C22) - a DnaJ/Hsp40 co-chaperone involved in protein folding, quality control, and associated with Parkinson's Disease.

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🧬 Gene Info

Gene Symbol	DNAJC22
Full Name	DnaJ Heat Shock Protein Family (Hsp40) Member C22
Aliases	DJC22, Hsp40
Chromosome	12q24.11
Protein Type	Chaperone
Function	DNAJC22 is a member of the DnaJ/Hsp40 protein family, which serves as co-chaperones for Hsp70 proteins.
Primary Expression	various tissues including brain, heart, liver, and kidney - Moderate expression in neuronal tissues - Localizes to cytoplasm and potentially ER compar
Amino Acids	70 aa
UniProt ID	Q8T5M0
NCBI Gene ID	79982
Ensembl ID	ENSG00000155792
GeneCards	DNAJC22
Human Protein Atlas	DNAJC22
J-domain	N-terminal (~70 aa)
Gly/Phe-rich	Middle
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DNAJC22 — AlphaFold Q8T5M0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJC22["DNAJC22"]
    neurodegeneration["neurodegeneration"]
    DNAJC22 -->|"implicated_in"| neurodegeneration
    style DNAJC22 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity