Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC24: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DnaJ Heat Shock Protein Family Member C24 |
| Chromosome | 9p13.3 |
| Protein Type | Chaperone |
| Function | is a member of the DNAJ/HSP40 family of molecular chaperones that facilitate protein folding, refolding, and clearance[@kampinga2019]. |
| Primary Expression | both neurons and glial cells, with particular enrichment in: |
| Amino Acids | 70 aa |
| UniProt ID | Q9H0Y5 |
| NCBI Gene ID | 120526 |
| Ensembl ID | ENSG00000160959 |
| OMIM | 614929 |
| N-terminal J-domain | The defining feature of DNAJ proteins, approximately 70 amino acids, containing the conserved HPD motif essential for HSP70 interaction |
| Glycine/phenylalanine-rich region | Flexible linker region potentially involved in protein-protein interactions |
| C-terminal substrate-binding region | May be involved in recognizing specific client proteins |
| Brain | Moderate expression across multiple brain regions |
| Bone marrow | High expression in hematopoietic tissues |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC24["DNAJC24"]
neurodegeneration["neurodegeneration"]
DNAJC24 -->|"implicated_in"| neurodegeneration
style DNAJC24 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DNAJC24 in their description or question text
No additional research found