Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DNAJC25 |
| Protein Type | Chaperone |
| Function | is a member of the DnaJ/Hsp40 family of co-chaperones that participate in cellular protein quality control mechanisms. |
| Primary Expression | various brain regions including the cortex, hippocampus, and cerebellum |
| Molecular Weight | 34 kDa |
| Amino Acids | 312 aa |
| GeneCards | DNAJC25 |
| Human Protein Atlas | DNAJC25 |
| Glycine-rich region | A flexible linker region containing glycine residues that may facilitate protein-protein interactions and provide flexibility between functional domains. |
| C-terminal substrate-binding domain | Region predicted to be involved in recognizing and binding client proteins, particularly those that are misfolded or partially unfolded. |
| Brain | Expressed in various brain regions including the cortex, hippocampus, and cerebellum. Expression has been detected in both neurons and supporting glial cells. |
| Peripheral tissues | Detected in liver, kidney, heart, and skeletal muscle at moderate levels. |
| Cellular compartments | Cytosolic localization with potential association with cellular membrane systems involved in protein quality control. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC25["DNAJC25"]
neurodegeneration["neurodegeneration"]
DNAJC25 -->|"implicated_in"| neurodegeneration
style DNAJC25 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||