Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC26: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DnaJ Heat Shock Protein Family Member C26 |
| Aliases | DNAJC26 |
| Chromosome | 4p16.3 |
| Protein Type | Chaperone |
| Function | Key functions include |
| Pathways | TGF-β Signaling |
| UniProt ID | Q9UQF2 |
| NCBI Gene ID | 9907 |
| OMIM | 604393 |
| mRNA Binding and Regulation | G3BP2 binds to specific mRNA sequences and regulates translation during stress[@matsumoto2015] |
| Stress Granule Assembly | Acts as a scaffold protein, nucleating stress granule formation through interactions with multiple SG components |
| Translation Repression | Participates in mechanisms that stall translation under stress conditions |
| mRNA Decay | Associates with machinery involved in mRNA degradation pathways |
| TDP-43 | Sequestration of TDP-43 in stress granules is a hallmark of ALS/FTD[@nonaka2023] |
| FUS | Another ALS/FTD-associated protein that localizes to stress granules |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC26["DNAJC26"]
neurodegeneration["neurodegeneration"]
DNAJC26 -->|"implicated_in"| neurodegeneration
style DNAJC26 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DNAJC26 in their description or question text
No additional research found