gene

DNAJC29

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC29: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for DNAJC29 Gene

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🧬 Gene Info

Gene Symbol	DNAJC29
Protein Type	Chaperone
Function	is a member of the DnaJ/Hsp40 family of co-chaperones that play critical roles in protein quality control mechanisms throughout the cell.
Primary Expression	various tissues, with notable expression in the brain, and has been investigated for its potential roles in neurodegenerative disease pathogenesis
Molecular Weight	38 kDa
Amino Acids	354 aa
GeneCards	DNAJC29
Human Protein Atlas	DNAJC29
Glycine/phenylalanine-rich region	A flexible linker region that may facilitate protein-protein interactions.
C-terminal substrate-binding domain	Responsible for recognizing and binding client proteins, typically containing multiple coiled-coil regions that mediate dimerization.
Testis	High expression in testis tissue, indicating potential functions in spermatogenesis.
Liver and kidney	Moderate expression in metabolic tissues.
Cardiac and skeletal muscle	Detectable expression in muscle tissues.
Hsp70 family members	Primary interaction partners through J domain-mediated binding
Hsp90	May coordinate with Hsp90-based chaperone complexes
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DNAJC29["DNAJC29"]
    neurodegeneration["neurodegeneration"]
    DNAJC29 -->|"implicated_in"| neurodegeneration
    style DNAJC29 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity